Simulating the Aggregation of
Globular Proteins in Solution at Various Salt Concentrations
By: Alex Olinger
Supervisors: Siddique Khan and Dr. Amit Chakrabarti
This program is funded by the National Science Foundation through grant number PHY-0851599.
Links to the people who made it all
happen!
Here
is my webpage!!! Check out my epic hyperlinks that contain useful information
about my project and I. It has become
important in the medical world to control the aggregation of proteins such as
insulin in order to obtain aggregates that make the protein deliverable to
patients in need. My simulations of
globular proteins attempt to model such aggregation. The conditions of constant temperature and
volume were chosen due to similar conditions seen in the human body. The monomers I used are spherical, have a
diameter of 3-4 nanometers, have a uniform charge distribution, and are in
solution. Therefore, there is a short
range attractive Van der Waals force between any two particles along with a
long range Coulombic repulsion. This
Coulombic repulsion can be screened by effectively adding a certain amount of
salt to the solution containing the proteins.
For more information, check out my links! Enjoy!!!!!